by Arango, Juan Manuel, Padro, Daniel, Blanco, Jorge, Lopez-Fernandez, Sonia, Castellnou, Pilar, Villa-Valverde, Palmira, Ruiz-Cabello, Jesús, Martin, Abraham and Carril, Mónica
Abstract:
Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that is based on the conjugation of custom-made small fluorinated building blocks, obtained by simple synthetic transformations, with carboxylated gold nanoparticles through a convenient phase-transfer process. The synthesis of four fluorinated building blocks with different chemical shifts in 19F nuclear magnetic resonance and varied functionalities is reported, along with their conjugation onto nanoparticles. Fluorinated nanoparticles of small core size obtained by this conjugation methodology and by direct synthesis presented high transverse relaxation times (T2) ranging from 518 to 1030 ms, and a large number of equivalent fluorine atoms per nanoparticle (340-1260 fluorine atoms), which made them potential candidates for 19F magnetic resonance related applications. Finally, nontargeted fluorinated nanoparticles were probed by performing in vivo19F magnetic resonance spectroscopy (19F MRS) in mice. Nanoparticles were detected at both 1 and 2 h after being injected. 19F MRI images were also acquired after either intravenous or subcutaneous injection. Their fate was studied by analyzing the gold content in tissues by ICP-MS. Thus, the present work provides a general fluorination strategy for nanoparticles and shows the potential use of small fluorinated nanoparticles in magnetic-resonance-related applications.
Reference:
Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging (Arango, Juan Manuel, Padro, Daniel, Blanco, Jorge, Lopez-Fernandez, Sonia, Castellnou, Pilar, Villa-Valverde, Palmira, Ruiz-Cabello, Jesús, Martin, Abraham and Carril, Mónica), In ACS applied materials & interfaces, volume 13, 2021.
Bibtex Entry:
@article{arango_fluorine_2021,
	title = {Fluorine {Labeling} of {Nanoparticles} and {In} {Vivo} {19F} {Magnetic} {Resonance} {Imaging}},
	volume = {13},
	issn = {1944-8252},
	doi = {10.1021/acsami.1c01291},
	abstract = {Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that is based on the conjugation of custom-made small fluorinated building blocks, obtained by simple synthetic transformations, with carboxylated gold nanoparticles through a convenient phase-transfer process. The synthesis of four fluorinated building blocks with different chemical shifts in 19F nuclear magnetic resonance and varied functionalities is reported, along with their conjugation onto nanoparticles. Fluorinated nanoparticles of small core size obtained by this conjugation methodology and by direct synthesis presented high transverse relaxation times (T2) ranging from 518 to 1030 ms, and a large number of equivalent fluorine atoms per nanoparticle (340-1260 fluorine atoms), which made them potential candidates for 19F magnetic resonance related applications. Finally, nontargeted fluorinated nanoparticles were probed by performing in vivo19F magnetic resonance spectroscopy (19F MRS) in mice. Nanoparticles were detected at both 1 and 2 h after being injected. 19F MRI images were also acquired after either intravenous or subcutaneous injection. Their fate was studied by analyzing the gold content in tissues by ICP-MS. Thus, the present work provides a general fluorination strategy for nanoparticles and shows the potential use of small fluorinated nanoparticles in magnetic-resonance-related applications.},
	language = {eng},
	number = {11},
	journal = {ACS applied materials & interfaces},
	author = {Arango, Juan Manuel and Padro, Daniel and Blanco, Jorge and Lopez-Fernandez, Sonia and Castellnou, Pilar and Villa-Valverde, Palmira and Ruiz-Cabello, Jes{'u}s and Martin, Abraham and Carril, M{'o}nica},
	month = mar,
	year = {2021},
	pmid = {33706503},
	keywords = {19F MRI, 19F MRS, fluorinated nanoparticles, fluorine labeling, in vivo},
	pages = {12941--12949},
	file = {Full Text:/Users/jruizcabello/Zotero/storage/44UESKUU/Arango et al. - 2021 - Fluorine Labeling of Nanoparticles and In Vivo 19F.pdf:application/pdf},
}