by Barnett, Brad P, Ruiz-Cabello, Jesus, Hota, Partha, Liddell, Robert, Walczak, Piotr, Howland, Valerie, Chacko, Vadappuram P, Kraitchman, Dara L, Arepally, Aravind and Bulte, Jeff W M
Abstract:
PurposeTo develop novel immunoprotective alginate microcapsule formulations containing perfluorocarbons (PFCs) that may increase cell function, provide immunoprotection for xenografted cells, and simultaneously enable multimodality imaging.Materials and MethodsAll animal experiments were approved by an Institutional Animal Care and Use Committee. Cadaveric human islet cells were encapsulated with alginate, poly-l-lysine, and perfluorooctyl bromide (PFOB) or perfluoropolyether (PFPE). In vitro viability and the glucose-stimulation index for insulin were determined over the course of 2 weeks and analyzed by using a cross-sectional time series regression model. The sensitivity of multimodality (computed tomography [CT], ultrasonography [US], and fluorine 19 [19F] magnetic resonance [MR] imaging) detection was determined for fluorocapsules embedded in gel phantoms. C57BL/6 mice intraperitoneally receiving 6000 PFOB-labeled (n = 6) or 6000 PFPE-labeled (n = 6) islet-containing fluorocapsules and control mice i…
Reference:
Fluorocapsules for Improved Function, Immunoprotection, and Visualization of Cellular Therapeutics with MR, US, and CT Imaging1 (Barnett, Brad P, Ruiz-Cabello, Jesus, Hota, Partha, Liddell, Robert, Walczak, Piotr, Howland, Valerie, Chacko, Vadappuram P, Kraitchman, Dara L, Arepally, Aravind and Bulte, Jeff W M), In Radiology, Radiological Society of North America, Inc., volume 258, 2011.
Bibtex Entry:
@article{Barnett:2011un,
author = {Barnett, Brad P and Ruiz-Cabello, Jesus and Hota, Partha and Liddell, Robert and Walczak, Piotr and Howland, Valerie and Chacko, Vadappuram P and Kraitchman, Dara L and Arepally, Aravind and Bulte, Jeff W M},
title = {{Fluorocapsules for Improved Function, Immunoprotection, and Visualization of Cellular Therapeutics with MR, US, and CT Imaging1}},
journal = {Radiology},
year = {2011},
volume = {258},
number = {1},
pages = {182--191},
publisher = {Radiological Society of North America, Inc.},
language = {English},
rating = {0},
date-added = {2013-08-27T07:36:33GMT},
date-modified = {2017-12-25T10:23:31GMT},
abstract = {PurposeTo develop novel immunoprotective alginate microcapsule formulations containing perfluorocarbons (PFCs) that may increase cell function, provide immunoprotection for xenografted cells, and simultaneously enable multimodality imaging.Materials and MethodsAll animal experiments were approved by an Institutional Animal Care and Use Committee. Cadaveric human islet cells were encapsulated with alginate, poly-l-lysine, and perfluorooctyl bromide (PFOB) or perfluoropolyether (PFPE). In vitro viability and the glucose-stimulation index for insulin were determined over the course of 2 weeks and analyzed by using a cross-sectional time series regression model. The sensitivity of multimodality (computed tomography [CT], ultrasonography [US], and fluorine 19 [19F] magnetic resonance [MR] imaging) detection was determined for fluorocapsules embedded in gel phantoms. C57BL/6 mice intraperitoneally receiving 6000 PFOB-labeled (n = 6) or 6000 PFPE-labeled (n = 6) islet-containing fluorocapsules and control mice i...},
uri = {url{papers3://publication/uuid/2FC23952-006A-4ED6-AD1A-265DED87223E}}
}