by Bhavesh, Riju, Lechuga-Vieco, Ana V, Ruiz-Cabello, Jesus and Herranz, Fernando
Abstract:
Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T₁-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
Reference:
T₁-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. (Bhavesh, Riju, Lechuga-Vieco, Ana V, Ruiz-Cabello, Jesus and Herranz, Fernando), In Nanomaterials, Multidisciplinary Digital Publishing Institute, volume 5, 2015.
Bibtex Entry:
@article{Bhavesh:2015hc,
author = {Bhavesh, Riju and Lechuga-Vieco, Ana V and Ruiz-Cabello, Jesus and Herranz, Fernando},
title = {{T₁-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis.}},
journal = {Nanomaterials},
year = {2015},
volume = {5},
number = {4},
pages = {1880--1890},
month = nov,
publisher = {Multidisciplinary Digital Publishing Institute},
affiliation = {Spanish Cardiovascular Research Centre (CNIC) and Spanish Pulmonary Diseases Network (CIBERES) C/Melchor Fern{'a}ndez-Almagro 3, 28029 Madrid, Spain. riju.bhavesh@cnic.es.},
doi = {10.3390/nano5041880},
pmid = {28347101},
pmcid = {PMC5304808},
language = {English},
rating = {0},
date-added = {2017-08-22T10:45:24GMT},
date-modified = {2018-11-22T21:14:03GMT},
abstract = {Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T₁-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.},
url = {http://www.mdpi.com/2079-4991/5/4/1880/},
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uri = {url{papers3://publication/doi/10.3390/nano5041880}}
}