by Bhavesh, Riju, Lechuga-Vieco, Ana V, Ruiz-Cabello, Jesus and Herranz, Fernando
Abstract:
Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T₁-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.
Reference:
T₁-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. (Bhavesh, Riju, Lechuga-Vieco, Ana V, Ruiz-Cabello, Jesus and Herranz, Fernando), In Nanomaterials, volume 5, 2015.
Bibtex Entry:
@article{bhavesh_t-mri_2015,
	title = {T₁-{MRI} {Fluorescent} {Iron} {Oxide} {Nanoparticles} by {Microwave} {Assisted} {Synthesis}.},
	volume = {5},
	url = {http://www.mdpi.com/2079-4991/5/4/1880/},
	doi = {10.3390/nano5041880},
	abstract = {Iron oxide nanoparticles have long been studied as a T₂ contrast agent in MRI due to their superparamagnetic behavior. T₁-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T₁-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice.},
	language = {English},
	number = {4},
	journal = {Nanomaterials},
	author = {Bhavesh, Riju and Lechuga-Vieco, Ana V and Ruiz-Cabello, Jesus and Herranz, Fernando},
	month = nov,
	year = {2015},
	pmid = {28347101},
	pmcid = {PMC5304808},
	note = {Publisher: Multidisciplinary Digital Publishing Institute},
	pages = {1880--1890}
}