by Cecconi, Alberto, Vilchez-Tschischke, Jean Paul, Mateo, Jesus, Sánchez-González, Javier, España, Samuel, Fernández-Jiménez, Rodrigo, López-Melgar, Beatriz, Fernández-Friera, Leticia, López-Martín, Gonzalo J, Fuster, Valentin, Ruiz-Cabello, Jesus and Ibáñez, Borja
Abstract:
Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI, 18F-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum 18F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.
Reference:
Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model. (Cecconi, Alberto, Vilchez-Tschischke, Jean Paul, Mateo, Jesus, Sánchez-González, Javier, España, Samuel, Fernández-Jiménez, Rodrigo, López-Melgar, Beatriz, Fernández-Friera, Leticia, López-Martín, Gonzalo J, Fuster, Valentin, Ruiz-Cabello, Jesus and Ibáñez, Borja), In Journal of Cardiovascular Translational Research, Springer US, volume 37, 2020.
Bibtex Entry:
@article{Cecconi:2020ct,
author = {Cecconi, Alberto and Vilchez-Tschischke, Jean Paul and Mateo, Jesus and S{'a}nchez-Gonz{'a}lez, Javier and Espa{~n}a, Samuel and Fern{'a}ndez-Jim{'e}nez, Rodrigo and L{'o}pez-Melgar, Beatriz and Fern{'a}ndez-Friera, Leticia and L{'o}pez-Mart{'i}n, Gonzalo J and Fuster, Valentin and Ruiz-Cabello, Jesus and Ib{'a}{~n}ez, Borja},
title = {{Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model.}},
journal = {Journal of Cardiovascular Translational Research},
year = {2020},
volume = {37},
number = {22},
pages = {1723--11},
month = mar,
publisher = {Springer US},
affiliation = {Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle de Melchor Fern{'a}ndez Almagro, 3, 28029, Madrid, Spain.},
doi = {10.1007/s12265-020-09974-7},
pmid = {32140929},
language = {English},
rating = {0},
date-added = {2020-03-17T18:46:07GMT},
date-modified = {2020-07-15T09:40:23GMT},
abstract = {Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI, 18F-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum 18F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.},
url = {http://link.springer.com/10.1007/s12265-020-09974-7},
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