by Claramunt, Rosa M, López, Concepción, López, Ana, Pérez-Medina, Carlos, Pérez-Torralba, Marta, Alkorta, Ibon, Elguero, José, Escames, Germaine and Acuña-Castroviejo, Darío
Abstract:
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, E(rel), between stacking and apical interaction energies of indazoles with the active site of the NOS enzyme has been established.
Reference:
Synthesis and biological evaluation of indazole derivatives. (Claramunt, Rosa M, López, Concepción, López, Ana, Pérez-Medina, Carlos, Pérez-Torralba, Marta, Alkorta, Ibon, Elguero, José, Escames, Germaine and Acuña-Castroviejo, Darío), In European journal of medicinal chemistry, volume 46, 2011.
Bibtex Entry:
@article{Claramunt:2011cu,
author = {Claramunt, Rosa M and L{'o}pez, Concepci{'o}n and L{'o}pez, Ana and P{'e}rez-Medina, Carlos and P{'e}rez-Torralba, Marta and Alkorta, Ibon and Elguero, Jos{'e} and Escames, Germaine and Acu{~n}a-Castroviejo, Dar{'i}o},
title = {{Synthesis and biological evaluation of indazole derivatives.}},
journal = {European journal of medicinal chemistry},
year = {2011},
volume = {46},
number = {4},
pages = {1439--1447},
month = apr,
affiliation = {Departamento de Qu{'i}mica Org{'a}nica y Bio-Org{'a}nica, Facultad de Ciencias, UNED, Senda del Rey 9, E-28040 Madrid, Spain. rclaramunt@ccia.uned.es},
doi = {10.1016/j.ejmech.2011.01.027},
pmid = {21334118},
language = {English},
rating = {0},
date-added = {2015-01-08T16:02:24GMT},
date-modified = {2020-07-09T13:27:50GMT},
abstract = {The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, E(rel), between stacking and apical interaction energies of indazoles with the active site of the NOS enzyme has been established.},
url = {http://linkinghub.elsevier.com/retrieve/pii/S0223523411000493},
uri = {url{papers3://publication/doi/10.1016/j.ejmech.2011.01.027}}
}