by Fernandez-Barahona, Irene, Gutiérrez, Lucía, Veintemillas-Verdaguer, Sabino, Pellico, Juan, del Puerto Morales, María, Catala, Mauro, Del Pozo, Miguel A, Ruiz-Cabello, Jesus and Herranz, Fernando
Abstract:
Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging.
Reference:
Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging (Fernandez-Barahona, Irene, Gutiérrez, Lucía, Veintemillas-Verdaguer, Sabino, Pellico, Juan, del Puerto Morales, María, Catala, Mauro, Del Pozo, Miguel A, Ruiz-Cabello, Jesus and Herranz, Fernando), In ACS Omega, American Chemical Society, volume 4, 2019.
Bibtex Entry:
@article{FernandezBarahona:2019kma,
author = {Fernandez-Barahona, Irene and Guti{'e}rrez, Luc{'i}a and Veintemillas-Verdaguer, Sabino and Pellico, Juan and del Puerto Morales, Mar{'i}a and Catala, Mauro and Del Pozo, Miguel A and Ruiz-Cabello, Jesus and Herranz, Fernando},
title = {{Cu-Doped Extremely Small Iron Oxide Nanoparticles with Large Longitudinal Relaxivity: One-Pot Synthesis and in Vivo Targeted Molecular Imaging}},
journal = {ACS Omega},
year = {2019},
volume = {4},
number = {2},
pages = {2719--2727},
month = feb,
publisher = {American Chemical Society},
doi = {10.1021/acsomega.8b03004},
language = {English},
rating = {0},
date-added = {2019-04-18T09:38:28GMT},
date-modified = {2019-04-18T09:42:50GMT},
abstract = {Synthesizing iron oxide nanoparticles for positive contrast in magnetic resonance imaging is the most promising approach to bring this nanomaterial back to the clinical field. The success of this approach depends on several aspects: the longitudinal relaxivity values, the complexity of the synthetic protocol, and the reproducibility of the synthesis. Here, we show our latest results on this goal. We have studied the effect of Cu doping on the physicochemical, magnetic, and relaxometric properties of iron oxide nanoparticles designed to provide positive contrast in magnetic resonance imaging. We have used a one-step, 10 min synthesis to produce nanoparticles with excellent colloidal stability. We have synthesized three different Cu-doped iron oxide nanoparticles showing modest to very large longitudinal relaxivity values. Finally, we have demonstrated the in vivo use of these kinds of nanoparticles both in angiography and targeted molecular imaging.},
url = {http://pubs.acs.org/doi/10.1021/acsomega.8b03004},
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uri = {url{papers3://publication/doi/10.1021/acsomega.8b03004}}
}