by Groult, Hugo, Ruiz-Cabello, Jesus, Pellico, Juan, Lechuga-Vieco, Ana V, Bhavesh, Riju, Zamai, Moreno, Almarza, Elena, Martín-Padura, Inés, Cantelar, Eugenio, Martínez-Alcázar, María P and Herranz, Fernando
Abstract:
Multifunctional nanoparticles are usually produced by sequential synthesis, with long multistep protocols. Our study reports a generic modular strategy for the parallel one-step multifunctionalization of different hydrophobic nanoparticles. The method was designed and developed by taking advantage of the natural noncovalent interactions between the fatty acid binding sites of the bovine serum albumin (BSA) and the aliphatic surfactants on different inorganic nanomaterials. As a general example of the approach, three different nanoparticlestextemdashiron oxide, upconverting nanophosphors, and gold nanospherestextemdashwere nanoemulsified in water with BSA. To support specific applications, multifunctional capability was incorporated with a variety of previously modified BSA modules. These modules include different conjugated groups, such as chelating agents for 68Ga or 89Zr and ligand molecules for enhanced in vivo targeting. A large library of 13 multimodal contrast agents was developed with this convergent strategy. This …
Reference:
Parallel Multifunctionalization of Nanoparticles: A One-Step Modular Approach for in Vivo Imaging (Groult, Hugo, Ruiz-Cabello, Jesus, Pellico, Juan, Lechuga-Vieco, Ana V, Bhavesh, Riju, Zamai, Moreno, Almarza, Elena, Martín-Padura, Inés, Cantelar, Eugenio, Martínez-Alcázar, María P and Herranz, Fernando), In Bioconjugate Chemistry, American Chemical Society, volume 26, 2014.
Bibtex Entry:
@article{Groult:2014ixa,
author = {Groult, Hugo and Ruiz-Cabello, Jesus and Pellico, Juan and Lechuga-Vieco, Ana V and Bhavesh, Riju and Zamai, Moreno and Almarza, Elena and Mart{'i}n-Padura, In{'e}s and Cantelar, Eugenio and Mart{'i}nez-Alc{'a}zar, Mar{'i}a P and Herranz, Fernando},
title = {{Parallel Multifunctionalization of Nanoparticles: A One-Step Modular Approach for in Vivo Imaging}},
journal = {Bioconjugate Chemistry},
year = {2014},
volume = {26},
number = {1},
pages = {153--160},
month = dec,
publisher = {American Chemical Society},
doi = {10.1021/bc500536y},
pmid = {25494619},
language = {English},
rating = {0},
date-added = {2017-08-22T10:44:40GMT},
date-modified = {2018-03-16T13:14:13GMT},
abstract = {Multifunctional nanoparticles are usually produced by sequential synthesis, with long multistep protocols. Our study reports a generic modular strategy for the parallel one-step multifunctionalization of different hydrophobic nanoparticles. The method was designed and developed by taking advantage of the natural noncovalent interactions between the fatty acid binding sites of the bovine serum albumin (BSA) and the aliphatic surfactants on different inorganic nanomaterials. As a general example of the approach, three different nanoparticles{textemdash}iron oxide, upconverting nanophosphors, and gold nanospheres{textemdash}were nanoemulsified in water with BSA. To support specific applications, multifunctional capability was incorporated with a variety of previously modified BSA modules. These modules include different conjugated groups, such as chelating agents for 68Ga or 89Zr and ligand molecules for enhanced in vivo targeting. A large library of 13 multimodal contrast agents was developed with this convergent strategy. This ...},
url = {http://pubs.acs.org/doi/abs/10.1021/bc500536y},
uri = {url{papers3://publication/doi/10.1021/bc500536y}}
}