by Groult, Hugo, Garcia-Alvarez, Isabel, Romero-Ramirez, Lorenzo, Nieto-Sampedro, Manuel, Herranz, Fernando, Fernandez-Mayoralas, Alfonso and Ruiz-Cabello, Jesus
Abstract:
The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy.
Reference:
Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides. (Groult, Hugo, Garcia-Alvarez, Isabel, Romero-Ramirez, Lorenzo, Nieto-Sampedro, Manuel, Herranz, Fernando, Fernandez-Mayoralas, Alfonso and Ruiz-Cabello, Jesus), In Nanomaterials, Multidisciplinary Digital Publishing Institute, volume 8, 2018.
Bibtex Entry:
@article{Groult:2018hqa,
author = {Groult, Hugo and Garcia-Alvarez, Isabel and Romero-Ramirez, Lorenzo and Nieto-Sampedro, Manuel and Herranz, Fernando and Fernandez-Mayoralas, Alfonso and Ruiz-Cabello, Jesus},
title = {{Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides.}},
journal = {Nanomaterials},
year = {2018},
volume = {8},
number = {8},
pages = {567},
month = jul,
publisher = {Multidisciplinary Digital Publishing Institute},
affiliation = {UMR CNRS 7266 LIENSs, Approches Mol{'e}culaires Environnement-Sant{'e} Environnement (AMES), Avenue Michel Crepeau, Universit{'e} de La Rochelle, 86073 La Rochelle, France. hugo.groult@univ-lr.fr.},
doi = {10.3390/nano8080567},
pmid = {30044386},
pmcid = {PMC6116232},
language = {English},
rating = {0},
date-added = {2018-11-22T21:02:28GMT},
date-modified = {2019-10-09T09:29:12GMT},
abstract = {The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy.},
url = {http://www.mdpi.com/2079-4991/8/8/567},
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uri = {url{papers3://publication/doi/10.3390/nano8080567}}
}