by Mejías, Raquel, Pérez-Yagüe, Sonia, Roca, Alejandro G, Pérez, Nicolás, Villanueva, Angeles, Cañete, Magdalena, Mañes, Santos, Ruiz-Cabello, Jesus, Benito, Marina, Labarta, Amilcar, Batlle, Xavier, Veintemillas-Verdaguer, Sabino, Morales, M Puerto, Barber, Domingo F and Serna, Carlos J
Abstract:
BACKGROUND & AIM:Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. MATERIAL & METHOD:We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. RESULTS:In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
Reference:
Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles. (Mejías, Raquel, Pérez-Yagüe, Sonia, Roca, Alejandro G, Pérez, Nicolás, Villanueva, Angeles, Cañete, Magdalena, Mañes, Santos, Ruiz-Cabello, Jesus, Benito, Marina, Labarta, Amilcar, Batlle, Xavier, Veintemillas-Verdaguer, Sabino, Morales, M Puerto, Barber, Domingo F and Serna, Carlos J), In Nanomedicine (London, England), Future Medicine Ltd London, UK, volume 5, 2010.
Bibtex Entry:
@article{Mejias:2010bnb,
author = {Mej{'i}as, Raquel and P{'e}rez-Yag{"u}e, Sonia and Roca, Alejandro G and P{'e}rez, Nicol{'a}s and Villanueva, Angeles and Ca{~n}ete, Magdalena and Ma{~n}es, Santos and Ruiz-Cabello, Jesus and Benito, Marina and Labarta, Amilcar and Batlle, Xavier and Veintemillas-Verdaguer, Sabino and Morales, M Puerto and Barber, Domingo F and Serna, Carlos J},
title = {{Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.}},
journal = {Nanomedicine (London, England)},
year = {2010},
volume = {5},
number = {3},
pages = {397--408},
month = apr,
publisher = {Future Medicine Ltd London, UK},
affiliation = {Centro Nacional de Biotecnolog{'i}a/CSIC, Spain.},
doi = {10.2217/nnm.10.15},
pmid = {20394533},
language = {English},
rating = {0},
date-added = {2018-03-16T12:57:49GMT},
date-modified = {2020-07-09T13:27:51GMT},
abstract = {BACKGROUND {&} AIM:Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures.
MATERIAL {&} METHOD:We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity.
RESULTS:In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.},
url = {http://www.futuremedicine.com/doi/10.2217/nnm.10.15},
uri = {url{papers3://publication/doi/10.2217/nnm.10.15}}
}