by Mejías, Raquel, Pérez-Yagüe, Sonia, Roca, Alejandro G, Pérez, Nicolás, Villanueva, Angeles, Cañete, Magdalena, Mañes, Santos, Ruiz-Cabello, Jesus, Benito, Marina, Labarta, Amilcar, Batlle, Xavier, Veintemillas-Verdaguer, Sabino, Morales, M Puerto, Barber, Domingo F and Serna, Carlos J
Abstract:
BACKGROUND & AIM:Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. MATERIAL & METHOD:We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (textless 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. RESULTS:In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
Reference:
Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles. (Mejías, Raquel, Pérez-Yagüe, Sonia, Roca, Alejandro G, Pérez, Nicolás, Villanueva, Angeles, Cañete, Magdalena, Mañes, Santos, Ruiz-Cabello, Jesus, Benito, Marina, Labarta, Amilcar, Batlle, Xavier, Veintemillas-Verdaguer, Sabino, Morales, M Puerto, Barber, Domingo F and Serna, Carlos J), In Nanomedicine (London, England), volume 5, 2010.
Bibtex Entry:
@article{mejias_liver_2010,
	title = {Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.},
	volume = {5},
	url = {http://www.futuremedicine.com/doi/10.2217/nnm.10.15},
	doi = {10.2217/nnm.10.15},
	abstract = {BACKGROUND & AIM:Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures. MATERIAL & METHOD:We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size ({textless} 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity. RESULTS:In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.},
	language = {English},
	number = {3},
	journal = {Nanomedicine (London, England)},
	author = {Mejías, Raquel and Pérez-Yagüe, Sonia and Roca, Alejandro G and Pérez, Nicolás and Villanueva, Angeles and Cañete, Magdalena and Mañes, Santos and Ruiz-Cabello, Jesus and Benito, Marina and Labarta, Amilcar and Batlle, Xavier and Veintemillas-Verdaguer, Sabino and Morales, M Puerto and Barber, Domingo F and Serna, Carlos J},
	month = apr,
	year = {2010},
	pmid = {20394533},
	note = {Publisher: Future Medicine Ltd London, UK},
	pages = {397--408}
}