by Palomo, Jose M and Filice, Marco
Abstract:
The development of new and successful biotransformation processes of key interest in medicinal and pharmaceutical chemistry involves creating new biocatalysts with improved or even new activities and selectivities. This review emphasizes the new emerging developed strategies to achieve this goal, site-selective chemical modification of enzymes using tailor-made peptides, specific insertion of metals or organometallic complexes into proteins producing bio-catalysts with multiple activities and computational design for creating evolved artificial enzymes with non-natural synthetic catalytic activities.
Reference:
New emerging bio-catalysts design in biotransformations. (Palomo, Jose M and Filice, Marco), In Biotechnology Advances, volume 33, 2015.
Bibtex Entry:
@article{Palomo:2015ega,
author = {Palomo, Jose M and Filice, Marco},
title = {{New emerging bio-catalysts design in biotransformations.}},
journal = {Biotechnology Advances},
year = {2015},
volume = {33},
number = {5},
pages = {605--613},
month = sep,
affiliation = {Departamento of Biocatalisis, Instituto de Catalisis (CSIC), Marie Curie 2, Cantoblanco 28049, Madrid, Spain. Electronic address: josempalomo@icp.csic.es.},
doi = {10.1016/j.biotechadv.2014.12.010},
pmid = {25560932},
language = {English},
rating = {0},
date-added = {2018-03-16T12:40:45GMT},
date-modified = {2018-03-16T13:14:13GMT},
abstract = {The development of new and successful biotransformation processes of key interest in medicinal and pharmaceutical chemistry involves creating new biocatalysts with improved or even new activities and selectivities. This review emphasizes the new emerging developed strategies to achieve this goal, site-selective chemical modification of enzymes using tailor-made peptides, specific insertion of metals or organometallic complexes into proteins producing bio-catalysts with multiple activities and computational design for creating evolved artificial enzymes with non-natural synthetic catalytic activities.},
url = {http://linkinghub.elsevier.com/retrieve/pii/S0734975014001979},
uri = {url{papers3://publication/doi/10.1016/j.biotechadv.2014.12.010}}
}