by Pavillard, Luís E, Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A B, Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A, Quiles, Jose L, Bullón, Pedro, Ruiz-Cabello, Jesus and Cordero, Mario D
Abstract:
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 inhibition may attenuate diet-induced cardiac injury. Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks. Genetic ablation of NLRP3 protected against this damage by autophagy induction and apoptotic control. Furthermore, NLRP3 inhibition by the selective small molecule MCC950 resulted in similar autophagy induction and apoptotic control in hearts after diets. These data were reproduced in THP-1 cells treated with MCC950 and cultured in media supplemented with serum from mice dosed with MCC950 and fed with diets. NLRP3 inhibition exerted beneficial metabolic, and autophagic adaptations in hearts from obesogenic diets. The inhibition of NLRP3 activation may hold promise in the treatment of metabolic and cardiovascular diseases.
Reference:
NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. (Pavillard, Luís E, Cañadas-Lozano, Diego, Alcocer-Gómez, Elísabet, Marín-Aguilar, Fabiola, Pereira, Sheila, Robertson, Avril A B, Muntané, Jordi, Ryffel, Bernhard, Cooper, Matthew A, Quiles, Jose L, Bullón, Pedro, Ruiz-Cabello, Jesus and Cordero, Mario D), In Oncotarget, volume 8, 2017.
Bibtex Entry:
@article{Pavillard:2017ex,
author = {Pavillard, Lu{'i}s E and Ca{~n}adas-Lozano, Diego and Alcocer-G{'o}mez, El{'i}sabet and Mar{'i}n-Aguilar, Fabiola and Pereira, Sheila and Robertson, Avril A B and Muntan{'e}, Jordi and Ryffel, Bernhard and Cooper, Matthew A and Quiles, Jose L and Bull{'o}n, Pedro and Ruiz-Cabello, Jesus and Cordero, Mario D},
title = {{NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction.}},
journal = {Oncotarget},
year = {2017},
volume = {8},
number = {59},
pages = {99740--99756},
month = nov,
affiliation = {Research Laboratory, Oral Medicine Department, University of Sevilla, Sevilla, Spain.},
doi = {10.18632/oncotarget.20763},
pmid = {29245937},
pmcid = {PMC5725128},
language = {English},
rating = {0},
date-added = {2018-01-23T14:31:14GMT},
date-modified = {2018-11-22T21:14:03GMT},
abstract = {The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 inhibition may attenuate diet-induced cardiac injury. Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks. Genetic ablation of NLRP3 protected against this damage by autophagy induction and apoptotic control. Furthermore, NLRP3 inhibition by the selective small molecule MCC950 resulted in similar autophagy induction and apoptotic control in hearts after diets. These data were reproduced in THP-1 cells treated with MCC950 and cultured in media supplemented with serum from mice dosed with MCC950 and fed with diets. NLRP3 inhibition exerted beneficial metabolic, and autophagic adaptations in hearts from obesogenic diets. The inhibition of NLRP3 activation may hold promise in the treatment of metabolic and cardiovascular diseases.},
url = {http://www.oncotarget.com/fulltext/20763},
local-url = {file://localhost/Users/jruizcabello/Documents/JRC/biblio/Papers-folder/Library.papers3/Files/85/85140852-D952-4A8E-8672-9747EB516378.pdf},
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uri = {url{papers3://publication/doi/10.18632/oncotarget.20763}}
}