by Pellico, Juan, Fernández-Barahona, Irene, Ruiz-Cabello, Jesús, Gutiérrez, Lucía, Muñoz-Hernando, María, Sánchez-Guisado, María J., Aiestaran-Zelaia, Irati, Martínez-Parra, Lydia, Rodríguez, Ignacio, Bentzon, Jacob and Herranz, Fernando
Abstract:
Vascular microcalcifications are associated with atherosclerosis plaque instability and, therefore, to increased mortality. Because of this key role, several imaging probes have been developed for their in vivo identification. Among them, [18F]FNa is the gold standard, showing a large uptake in the whole skeleton by positron emission tomography. Here, we push the field toward the combined anatomical and functional early characterization of atherosclerosis. For this, we have developed hydroxyapatite (HAP)-multitag, a bisphosphonate-functionalized 68Ga core-doped magnetic nanoparticle showing high affinity toward most common calcium salts present in microcalcifications, particularly HAP. We characterized this interaction in vitro and in vivo, showing a massive uptake in the atherosclerotic lesion identified by positron emission tomography (PET) and positive contrast magnetic resonance imaging (MRI). In addition, this accumulation was found to be dependent on the calcification progression, with a maximum uptake in the microcalcification stage. These results confirmed the ability of HAP-multitag to identify vascular calcifications by PET/(T1)MRI during the vulnerable stages of the plaque progression.
Reference:
HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis (Pellico, Juan, Fernández-Barahona, Irene, Ruiz-Cabello, Jesús, Gutiérrez, Lucía, Muñoz-Hernando, María, Sánchez-Guisado, María J., Aiestaran-Zelaia, Irati, Martínez-Parra, Lydia, Rodríguez, Ignacio, Bentzon, Jacob and Herranz, Fernando), In ACS applied materials & interfaces, volume 13, 2021.
Bibtex Entry:
@article{pellico_hap-multitag_2021,
	title = {{HAP}-{Multitag}, a {PET} and {Positive} {MRI} {Contrast} {Nanotracer} for the {Longitudinal} {Characterization} of {Vascular} {Calcifications} in {Atherosclerosis}},
	volume = {13},
	issn = {1944-8252},
	doi = {10.1021/acsami.1c13417},
	abstract = {Vascular microcalcifications are associated with atherosclerosis plaque instability and, therefore, to increased mortality. Because of this key role, several imaging probes have been developed for their in vivo identification. Among them, [18F]FNa is the gold standard, showing a large uptake in the whole skeleton by positron emission tomography. Here, we push the field toward the combined anatomical and functional early characterization of atherosclerosis. For this, we have developed hydroxyapatite (HAP)-multitag, a bisphosphonate-functionalized 68Ga core-doped magnetic nanoparticle showing high affinity toward most common calcium salts present in microcalcifications, particularly HAP. We characterized this interaction in vitro and in vivo, showing a massive uptake in the atherosclerotic lesion identified by positron emission tomography (PET) and positive contrast magnetic resonance imaging (MRI). In addition, this accumulation was found to be dependent on the calcification progression, with a maximum uptake in the microcalcification stage. These results confirmed the ability of HAP-multitag to identify vascular calcifications by PET/(T1)MRI during the vulnerable stages of the plaque progression.},
	language = {eng},
	number = {38},
	journal = {ACS applied materials & interfaces},
	author = {Pellico, Juan and Fern{'a}ndez-Barahona, Irene and Ruiz-Cabello, Jes{'u}s and Guti{'e}rrez, Luc{'i}a and Mu{~n}oz-Hernando, Mar{'i}a and S{'a}nchez-Guisado, Mar{'i}a J. and Aiestaran-Zelaia, Irati and Mart{'i}nez-Parra, Lydia and Rodr{'i}guez, Ignacio and Bentzon, Jacob and Herranz, Fernando},
	month = sep,
	year = {2021},
	pmid = {34529427},
	pmcid = {PMC8485330},
	keywords = {atherosclerosis, hydroxyapatite, nanotracer, PET/MRI, vascular calcifications},
	pages = {45279--45290},
	file = {Full Text:/Users/jruizcabello/Zotero/storage/I8BYX65U/Pellico et al. - 2021 - HAP-Multitag, a PET and Positive MRI Contrast Nano.pdf:application/pdf},
}