by Robles-Vera, Iñaki, de la Visitación, Néstor, Toral, Marta, Sánchez, Manuel, Romero, Miguel, Gómez-Guzmán, Manuel, Yang, Tao, Izquierdo-García, José L, Guerra-Hernández, Eduardo, Ruiz-Cabello, Jesus, Raizada, Mohan K, Perez-Vizcaino, Francisco, Jiménez, Rosario and Duarte, Juan
Abstract:
Many probiotics that affect gut microbial ecology have been shown to produce beneficial effects on renin-angiotensin-dependent rodent models and human hypertension. We hypothesized that Bifidobacterium breve CECT7263 (BFM) would attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Rats were randomly divided into five groups: control, DOCA-salt, treated DOCA-salt-BFM, treated DOCA-salt-butyrate, and treated DOCA-salt-acetate, for 5 weeks. BFM prevented the increase in systolic blood pressure, cardiac weight, and renal damage induced by DOCA-salt. BFM increased acetate-producing bacterial population and gut acetate levels, improved colonic integrity, normalized endotoxemia, plasma trimethylamine (TMA) levels, and restored the Th17 and Treg content in mesenteric lymph nodes and aorta. Furthermore, BFM improved nitric oxide-dependent vasorelaxation induced by acetylcholine in aortic rings and reduced NADPH oxidase activity in DOCA-salt animals. These protective effects were mimicked by acetate, but not by butyrate supplementation. These data demonstrate that BFM induces changes in gut microbiota linked with attenuation of endothelial dysfunction and increase in blood pressure in this low-renin form of hypertension. These beneficial effects seem to be mediated by increased acetate and reduced TMA production by gut microbiota, thus, improving gut integrity and restoring Th17/Tregs polarization and endotoxemia.
Reference:
Probiotic Bifidobacterium breve prevents DOCA-salt hypertension. (Robles-Vera, Iñaki, de la Visitación, Néstor, Toral, Marta, Sánchez, Manuel, Romero, Miguel, Gómez-Guzmán, Manuel, Yang, Tao, Izquierdo-García, José L, Guerra-Hernández, Eduardo, Ruiz-Cabello, Jesus, Raizada, Mohan K, Perez-Vizcaino, Francisco, Jiménez, Rosario and Duarte, Juan), In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, John Wiley & Sons, Ltd, volume 34, 2020.
Bibtex Entry:
@article{RoblesVera:2020db,
author = {Robles-Vera, I{~n}aki and de la Visitaci{'o}n, N{'e}stor and Toral, Marta and S{'a}nchez, Manuel and Romero, Miguel and G{'o}mez-Guzm{'a}n, Manuel and Yang, Tao and Izquierdo-Garc{'i}a, Jos{'e} L and Guerra-Hern{'a}ndez, Eduardo and Ruiz-Cabello, Jesus and Raizada, Mohan K and Perez-Vizcaino, Francisco and Jim{'e}nez, Rosario and Duarte, Juan},
title = {{Probiotic Bifidobacterium breve prevents DOCA-salt hypertension.}},
journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
year = {2020},
volume = {34},
number = {10},
pages = {13626--13640},
month = aug,
publisher = {John Wiley {&} Sons, Ltd},
affiliation = {Department of Pharmacology, School of Pharmacy and Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.},
doi = {10.1096/fj.202001532R},
pmid = {32780919},
language = {English},
rating = {0},
date-added = {2020-10-07T08:36:17GMT},
date-modified = {2020-10-13T14:28:59GMT},
abstract = {Many probiotics that affect gut microbial ecology have been shown to produce beneficial effects on renin-angiotensin-dependent rodent models and human hypertension. We hypothesized that Bifidobacterium breve CECT7263 (BFM) would attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Rats were randomly divided into five groups: control, DOCA-salt, treated DOCA-salt-BFM, treated DOCA-salt-butyrate, and treated DOCA-salt-acetate, for 5~weeks. BFM prevented the increase in systolic blood pressure, cardiac weight, and renal damage induced by DOCA-salt. BFM increased acetate-producing bacterial population and gut acetate levels, improved colonic integrity, normalized endotoxemia, plasma trimethylamine (TMA) levels, and restored the Th17 and Treg content in mesenteric lymph nodes and aorta. Furthermore, BFM improved nitric oxide-dependent vasorelaxation induced by acetylcholine in aortic rings and reduced NADPH oxidase activity in DOCA-salt animals. These protective effects were mimicked by acetate, but not by butyrate supplementation. These data demonstrate that BFM induces changes in gut microbiota linked with attenuation of endothelial dysfunction and increase in blood pressure in this low-renin form of hypertension. These beneficial effects seem to be mediated by increased acetate and reduced TMA production by gut microbiota, thus, improving gut integrity and restoring Th17/Tregs polarization and endotoxemia.},
url = {https://onlinelibrary.wiley.com/doi/10.1096/fj.202001532R},
uri = {url{papers3://publication/doi/10.1096/fj.202001532R}}
}