Semisynthetic peptide-lipase conjugates for improved biotransformations.

by | May 11, 2021

by Romero, Oscar, Filice, Marco, de las Rivas, Blanca, Carrasco-Lopez, Cesar, Klett, Javier, Morreale, Antonio, Hermoso, Juan A, Guisan, Jose M, Abian, Olga and Palomo, Jose M
Abstract:
An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.
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Reference:
Semisynthetic peptide-lipase conjugates for improved biotransformations. (Romero, Oscar, Filice, Marco, de las Rivas, Blanca, Carrasco-Lopez, Cesar, Klett, Javier, Morreale, Antonio, Hermoso, Juan A, Guisan, Jose M, Abian, Olga and Palomo, Jose M), In Chemical communications (Cambridge, England), The Royal Society of Chemistry, volume 48, 2012.
Bibtex Entry:
@article{Romero:2012dl,
author = {Romero, Oscar and Filice, Marco and de las Rivas, Blanca and Carrasco-Lopez, Cesar and Klett, Javier and Morreale, Antonio and Hermoso, Juan A and Guisan, Jose M and Abian, Olga and Palomo, Jose M},
title = {{Semisynthetic peptide-lipase conjugates for improved biotransformations.}},
journal = {Chemical communications (Cambridge, England)},
year = {2012},
volume = {48},
number = {72},
pages = {9053--9055},
month = sep,
publisher = {The Royal Society of Chemistry},
affiliation = {Departamento de Biocat{'a}lisis, Instituto de Cat{'a}lisis (CSIC), Marie Curie 2, Cantoblanco, CampusUAM, 28049 Madrid, Spain.},
doi = {10.1039/c2cc34816k},
pmid = {22858661},
language = {English},
rating = {0},
date-added = {2016-12-12T13:04:25GMT},
date-modified = {2020-07-09T13:27:50GMT},
abstract = {An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.},
url = {http://xlink.rsc.org/?DOI=c2cc34816k},
uri = {url{papers3://publication/doi/10.1039/c2cc34816k}}
}