by Roth, Yiftach, Tichler, Thomas, Kostenich, Genady, Ruiz-Cabello, Jesus, Maier, Stephan E, Cohen, Jack S, Orenstein, Arie and Mardor, Yael
Abstract:
PURPOSE: To evaluate the use of diffusion-weighted magnetic resonance (MR) imaging with standard and high b values for pretreatment prediction and early detection of tumor response to various antineoplastic therapies in an animal model. MATERIALS AND METHODS: Mice bearing C26 colon carcinoma tumors were treated with doxorubicin (n = 25) and with aminolevulinic acidtextendashbased photodynamic therapy (n = 23). Fourteen mice served as controls. Conventional T2-weighted fast spin-echo and diffusion-weighted MR images were acquired once before therapy and at 6, 24, and 48 hours after treatment. Pretreatment and early (1textendash2 days) posttreatment water diffusion parameters were calculated and compared with later changes in tumor volumes measured on conventional MR images by using the Pearson correlation test. RESULTS: In chemotherapy-treated tumors, a significant correlation (P < .002, r = 0.6) was observed between diffusion parameters that reflected tumor viability, measured prior to treatment, and changes in tumor volum…
Reference:
High-b-Value Diffusion-weighted MR Imaging for Pretreatment Prediction and Early Monitoring of Tumor Response to Therapy in Mice1 (Roth, Yiftach, Tichler, Thomas, Kostenich, Genady, Ruiz-Cabello, Jesus, Maier, Stephan E, Cohen, Jack S, Orenstein, Arie and Mardor, Yael), In Radiology, Radiological Society of North America, volume 232, 2004.
Bibtex Entry:
@article{Roth:2004ig,
author = {Roth, Yiftach and Tichler, Thomas and Kostenich, Genady and Ruiz-Cabello, Jesus and Maier, Stephan E and Cohen, Jack S and Orenstein, Arie and Mardor, Yael},
title = {{High-b-Value Diffusion-weighted MR Imaging for Pretreatment Prediction and Early Monitoring of Tumor Response to Therapy in Mice1}},
journal = {Radiology},
year = {2004},
volume = {232},
number = {3},
pages = {685--692},
month = sep,
publisher = {Radiological Society of North America},
doi = {10.1148/radiol.2322030778},
pmid = {15215551},
isbn = {2322030778},
language = {English},
rating = {0},
date-added = {2015-03-30T15:02:37GMT},
date-modified = {2020-07-09T13:27:45GMT},
abstract = {PURPOSE: To evaluate the use of diffusion-weighted magnetic resonance (MR) imaging with standard and high b values for pretreatment prediction and early detection of tumor response to various antineoplastic therapies in an animal model. MATERIALS AND METHODS: Mice bearing C26 colon carcinoma tumors were treated with doxorubicin (n = 25) and with aminolevulinic acid{textendash}based photodynamic therapy (n = 23). Fourteen mice served as controls. Conventional T2-weighted fast spin-echo and diffusion-weighted MR images were acquired once before therapy and at 6, 24, and 48 hours after treatment. Pretreatment and early (1{textendash}2 days) posttreatment water diffusion parameters were calculated and compared with later changes in tumor volumes measured on conventional MR images by using the Pearson correlation test. RESULTS: In chemotherapy-treated tumors, a significant correlation (P < .002, r = 0.6) was observed between diffusion parameters that reflected tumor viability, measured prior to treatment, and changes in tumor volum...},
url = {http://pubs.rsna.org/doi/abs/10.1148/radiol.2322030778},
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uri = {url{papers3://publication/doi/10.1148/radiol.2322030778}}
}