by Salinas, Beatriz, Ruiz-Cabello, Jesus, Lechuga-Vieco, Ana V, Benito, Marina and Herranz, Fernando
Abstract:
The use of click chemistry reactions for the functionalization of nanoparticles is particularly useful to modify the surface in a well-defined manner and to enhance the targeting properties, thus facilitating clinical translation. Here it is demonstrated that olefin metathesis can be used for the chemoselective functionalization of iron oxide nanoparticles with three different examples. This approach enables, in one step, the synthesis and functionalization of different water-stable magnetite-based particles from oleic acid-coated counterparts. The surface of the nanoparticles was completely characterized showing how the metathesis approach introduces a large number of hydrophilic molecules on their coating layer. As an example of the possible applications of these new nanocomposites, a focus was taken on atherosclerosis plaques. It is also demonstrated how the in vitro properties of one of the probes, particularly its Ca(2+) -binding properties, mediate their final in vivo use; that is, the selective accumulation in atherosclerotic plaques. This opens promising new applications to detect possible microcalcifications associated with plaque vulnerability. The accumulation of the new imaging tracers is demonstrated by in vivo magnetic resonance imaging of carotids and aorta in the ApoE(-/-) mouse model and the results were confirmed by histology.
Reference:
Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for In Vivo Characterization of Atherosclerosis Plaque. (Salinas, Beatriz, Ruiz-Cabello, Jesus, Lechuga-Vieco, Ana V, Benito, Marina and Herranz, Fernando), In Chemistry (Weinheim an der Bergstrasse, Germany), WILEY-VCH Verlag, volume 21, 2015.
Bibtex Entry:
@article{Salinas:2015bxb,
author = {Salinas, Beatriz and Ruiz-Cabello, Jesus and Lechuga-Vieco, Ana V and Benito, Marina and Herranz, Fernando},
title = {{Surface-Functionalized Nanoparticles by Olefin Metathesis: A Chemoselective Approach for In Vivo Characterization of Atherosclerosis Plaque.}},
journal = {Chemistry (Weinheim an der Bergstrasse, Germany)},
year = {2015},
volume = {21},
number = {29},
pages = {10450--10456},
month = jul,
publisher = {WILEY-VCH Verlag},
affiliation = {Advanced Imaging Unit, Fundaci{'o}n Centro Nacional de Investigaciones Cardiovasculares (CNIC) and CIBER de enfermedades respiratorias(CIBERES), C/Melchor Fern{'a}ndez-Almagro 3. 28029 Madrid (Spain).},
doi = {10.1002/chem.201500458},
pmid = {26096657},
language = {English},
rating = {0},
date-added = {2017-08-22T10:45:30GMT},
date-modified = {2019-10-09T09:29:12GMT},
abstract = {The use of click chemistry reactions for the functionalization of nanoparticles is particularly useful to modify the surface in a well-defined manner and to enhance the targeting properties, thus facilitating clinical translation. Here it is demonstrated that olefin metathesis can be used for the chemoselective functionalization of iron oxide nanoparticles with three different examples. This approach enables, in one step, the synthesis and functionalization of different water-stable magnetite-based particles from oleic acid-coated counterparts. The surface of the nanoparticles was completely characterized showing how the metathesis approach introduces a large number of hydrophilic molecules on their coating layer. As an example of the possible applications of these new nanocomposites, a focus was taken on atherosclerosis plaques. It is also demonstrated how the in vitro properties of one of the probes, particularly its Ca(2+) -binding properties, mediate their final in vivo use; that is, the selective accumulation in atherosclerotic plaques. This opens promising new applications to detect possible microcalcifications associated with plaque vulnerability. The accumulation of the new imaging tracers is demonstrated by in vivo magnetic resonance imaging of carotids and aorta in the ApoE(-/-) mouse model and the results were confirmed by histology.},
url = {http://doi.wiley.com/10.1002/chem.201500458},
uri = {url{papers3://publication/doi/10.1002/chem.201500458}}
}