by Sánchez, Alfredo, Ovejero Paredes, Karina, Ruiz-Cabello, Jesus, Martinez-Ruiz, Paloma, Pingarron, Jose Manuel, Villalonga, Reynaldo and Filice, Marco
Abstract:
In the recent years, targeted cancer theranosis -the concomitant therapeutic treatment and selective visualization of cancerous tissue- has become a powerful strategy to improve patient prognosis. In this context, targeted multimodal molecular imaging -the combination of different imaging modalities overcoming their individual limitations- has attracted great attention. Due to their unique properties, advanced nanomaterials have taken center stage in the development of theranostics. In this work, we report a novel Janus nanoplatform by combining a Fe3O4NPs/mesoporous silica core@shell face together with an Au nanoparticle face. Due to its anisotropy, this hybrid nanomaterial enabled the orthogonal site-selective modification of each face permitting the incorporation of a targeting peptide for cancer detection (cRGD) and a fluorescent dye. Due to the intrinsic characteristics of this Janus nanoplatform together with those selectively generated on their surfaces, the resulting hybrid nanocarrier successfully promoted the in vivo tumor-targeted multimodal imaging by magnetic resonance (Fe3O4 core), computed tomography (AuNP face) and fluorescent tracking (fluorescent dye loading) in fibrosarcoma-bearing mouse model. The achieved results endorse these hybrid Janus nanoparticles as a powerful and flexible platform with integrated imaging and carrier functionalities to be equipped with therapeutic features to generate an advanced multifunctional nanocarrier for targeted cancer theranosis.
Reference:
Hybrid Decorated Core@Shell Janus Nanoparticles As Flexible Platform For Targeted Multimodal Molecular Bioimaging Of Cancer. (Sánchez, Alfredo, Ovejero Paredes, Karina, Ruiz-Cabello, Jesus, Martinez-Ruiz, Paloma, Pingarron, Jose Manuel, Villalonga, Reynaldo and Filice, Marco), In ACS Applied Materials & Interfaces, American Chemical Society, 2018.
Bibtex Entry:
@article{Sanchez:2018eoa,
author = {S{'a}nchez, Alfredo and Ovejero Paredes, Karina and Ruiz-Cabello, Jesus and Martinez-Ruiz, Paloma and Pingarron, Jose Manuel and Villalonga, Reynaldo and Filice, Marco},
title = {{Hybrid Decorated Core@Shell Janus Nanoparticles As Flexible Platform For Targeted Multimodal Molecular Bioimaging Of Cancer.}},
journal = {ACS Applied Materials {&} Interfaces},
year = {2018},
pages = {acsami.8b10452},
month = aug,
publisher = {American Chemical Society},
doi = {10.1021/acsami.8b10452},
pmid = {30141615},
language = {English},
rating = {0},
date-added = {2018-09-04T13:01:28GMT},
date-modified = {2018-10-13T15:35:28GMT},
abstract = {In the recent years, targeted cancer theranosis -the concomitant therapeutic treatment and selective visualization of cancerous tissue- has become a powerful strategy to improve patient prognosis. In this context, targeted multimodal molecular imaging -the combination of different imaging modalities overcoming their individual limitations- has attracted great attention. Due to their unique properties, advanced nanomaterials have taken center stage in the development of theranostics. In this work, we report a novel Janus nanoplatform by combining a Fe3O4NPs/mesoporous silica core@shell face together with an Au nanoparticle face. Due to its anisotropy, this hybrid nanomaterial enabled the orthogonal site-selective modification of each face permitting the incorporation of a targeting peptide for cancer detection (cRGD) and a fluorescent dye. Due to the intrinsic characteristics of this Janus nanoplatform together with those selectively generated on their surfaces, the resulting hybrid nanocarrier successfully promoted the in vivo tumor-targeted multimodal imaging by magnetic resonance (Fe3O4 core), computed tomography (AuNP face) and fluorescent tracking (fluorescent dye loading) in fibrosarcoma-bearing mouse model. The achieved results endorse these hybrid Janus nanoparticles as a powerful and flexible platform with integrated imaging and carrier functionalities to be equipped with therapeutic features to generate an advanced multifunctional nanocarrier for targeted cancer theranosis.},
url = {http://pubs.acs.org/doi/10.1021/acsami.8b10452},
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uri = {url{papers3://publication/doi/10.1021/acsami.8b10452}}
}