by Sreeramkumar, Vinatha, Adrover, José M, Ballesteros, Ivan, Cuartero, Maria Isabel, Rossaint, Jan, Bilbao, Izaskun, Nácher, Maria, Pitaval, Christophe, Radovanovic, Irena, Fukui, Yoshinori, McEver, Rodger P, Filippi, Marie-Dominique, Lizasoain, Ignacio, Ruiz-Cabello, Jesus, Zarbock, Alexander, Moro, María A and Hidalgo, Andrés
Abstract:
Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils’ bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.
Reference:
Neutrophils scan for activated platelets to initiate inflammation. (Sreeramkumar, Vinatha, Adrover, José M, Ballesteros, Ivan, Cuartero, Maria Isabel, Rossaint, Jan, Bilbao, Izaskun, Nácher, Maria, Pitaval, Christophe, Radovanovic, Irena, Fukui, Yoshinori, McEver, Rodger P, Filippi, Marie-Dominique, Lizasoain, Ignacio, Ruiz-Cabello, Jesus, Zarbock, Alexander, Moro, María A and Hidalgo, Andrés), In Science, volume 346, 2014.
Bibtex Entry:
@article{Sreeramkumar:2014drb,
author = {Sreeramkumar, Vinatha and Adrover, Jos{'e} M and Ballesteros, Ivan and Cuartero, Maria Isabel and Rossaint, Jan and Bilbao, Izaskun and N{'a}cher, Maria and Pitaval, Christophe and Radovanovic, Irena and Fukui, Yoshinori and McEver, Rodger P and Filippi, Marie-Dominique and Lizasoain, Ignacio and Ruiz-Cabello, Jesus and Zarbock, Alexander and Moro, Mar{'i}a A and Hidalgo, Andr{'e}s},
title = {{Neutrophils scan for activated platelets to initiate inflammation.}},
journal = {Science},
year = {2014},
volume = {346},
number = {6214},
pages = {1234--1238},
month = dec,
affiliation = {Department of Atherothrombosis, Imaging and Epidemiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.},
doi = {10.1126/science.1256478},
pmid = {25477463},
pmcid = {PMC4280847},
language = {English},
rating = {0},
date-added = {2017-07-31T09:22:08GMT},
date-modified = {2020-07-09T13:27:49GMT},
abstract = {Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.},
url = {http://www.sciencemag.org/cgi/doi/10.1126/science.1256478},
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uri = {url{papers3://publication/doi/10.1126/science.1256478}}
}