by van Zijl, P C, Chesnick, A S, DesPres, D, Moonen, C T, Ruiz-Cabello, J and van Gelderen, P
Abstract:
Metabolism of [1-13C]-glucose was studied in situ in cat brain using gradient-enhanced proton-detected heteronuclear spectroscopy. Proton detection of [1-13C]-glucose, [3-13C]-lactate, 4-[13C]-glutamine, 4-[13C]-glutamate and the combined signals 2-[13C]-glutamate/glutamine and 3-[13C]-glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two-dimensional [1H-13C]-spectra demonstrate the possibility of in situ spectral assignment with 1H sensitivity and 13C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabolism.
Reference:
In vivo proton spectroscopy and spectroscopic imaging of [1-13C]-glucose and its metabolic products. (van Zijl, P C, Chesnick, A S, DesPres, D, Moonen, C T, Ruiz-Cabello, J and van Gelderen, P), In Magnetic Resonance in Medicine, volume 30, 1993.
Bibtex Entry:
@article{vanZijl:1993tja,
author = {van Zijl, P C and Chesnick, A S and DesPres, D and Moonen, C T and Ruiz-Cabello, J and van Gelderen, P},
title = {{In vivo proton spectroscopy and spectroscopic imaging of [1-13C]-glucose and its metabolic products.}},
journal = {Magnetic Resonance in Medicine},
year = {1993},
volume = {30},
number = {5},
pages = {544--551},
month = nov,
affiliation = {Department of Radiology, Johns Hopkins University Medical School, Baltimore, Maryland 21287.},
pmid = {8259054},
language = {English},
rating = {0},
date-added = {2015-03-30T15:05:16GMT},
date-modified = {2017-12-25T10:23:31GMT},
abstract = {Metabolism of [1-13C]-glucose was studied in situ in cat brain using gradient-enhanced proton-detected heteronuclear spectroscopy. Proton detection of [1-13C]-glucose, [3-13C]-lactate, 4-[13C]-glutamine, 4-[13C]-glutamate and the combined signals 2-[13C]-glutamate/glutamine and 3-[13C]-glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two-dimensional [1H-13C]-spectra demonstrate the possibility of in situ spectral assignment with 1H sensitivity and 13C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabolism.},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=8259054&retmode=ref&cmd=prlinks},
uri = {url{papers3://publication/uuid/11DDE541-8BD7-48F0-A91D-1D3DE2E23014}}
}