by Velasco, Carlos, Mateo, Jesus, Santos, Arnoldo, Mota-Cobian, Adriana, Herranz, Fernando, Pellico, Juan, Mota, Ruben A, España, Samuel and Ruiz-Cabello, Jesus
Abstract:
BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of (68)Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland-Altman plot. RESULTS:The capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between (68)Ga-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001). CONCLUSIONS:Assessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of (68)Ga/(68)Ge generators. Thus, (68)Ga-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use.
Reference:
Assessment of regional pulmonary blood flow using (68)Ga-DOTA PET. (Velasco, Carlos, Mateo, Jesus, Santos, Arnoldo, Mota-Cobian, Adriana, Herranz, Fernando, Pellico, Juan, Mota, Ruben A, España, Samuel and Ruiz-Cabello, Jesus), In EJNMMI Research, Springer Berlin Heidelberg, volume 7, 2017.
Bibtex Entry:
@article{Velasco:2017kw,
author = {Velasco, Carlos and Mateo, Jesus and Santos, Arnoldo and Mota-Cobian, Adriana and Herranz, Fernando and Pellico, Juan and Mota, Ruben A and Espa{~n}a, Samuel and Ruiz-Cabello, Jesus},
title = {{Assessment of regional pulmonary blood flow using (68)Ga-DOTA PET.}},
journal = {EJNMMI Research},
year = {2017},
volume = {7},
number = {1},
pages = {7},
month = dec,
publisher = {Springer Berlin Heidelberg},
affiliation = {Centro Nacional de Investigaciones Cardiovasculares Carlos III, C/Melchor Fern{'a}ndez Almagro 3, 28029, Madrid, Spain.},
doi = {10.1186/s13550-017-0259-2},
pmid = {28101850},
pmcid = {PMC5241570},
language = {English},
rating = {0},
date-added = {2017-01-25T10:37:44GMT},
date-modified = {2019-10-16T18:45:45GMT},
abstract = {BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of (68)Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal. Each radiotracer injection was performed simultaneously to the injection of fluorescent microspheres. PBF images were generated applying a two-compartment exchange model over the dynamic PET images. PET and microspheres values were compared by regression analysis and Bland-Altman plot.

RESULTS:The capability of the proposed technique to produce 3D regional PBF images was demonstrated. The correlation evaluation between (68)Ga-DOTA PET and microspheres showed a good and significant correlation (r = 0.74, P < 0.001).

CONCLUSIONS:Assessment of PBF with the proposed technique allows combining the high quantitative accuracy of PET imaging with the use of (68)Ga/(68)Ge generators. Thus, (68)Ga-DOTA PET emerges as a potential inexpensive method for measuring PBF in clinical settings with an extended use.},
url = {http://ejnmmires.springeropen.com/articles/10.1186/s13550-017-0259-2},
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}